Aryl cyanoguanidines: potassium channel activators and method of making same
US5011837A · kind A · utility
19Cited by
4References
36Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 8, 1989 |
| Grant date | Apr 30, 1991 |
| Priority date | — |
| Expiry date | May 8, 2009 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2602/10
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Novel compounds of the formula ##STR1## and tautomers thereof, wherein at least one of R.sub.2, R.sub.3 and R.sub.4 is a strong electron withdrawing group, are disclosed. These compounds possess potassium channel activating activity and, as such, are useful as antihypertensive agents. Advantageously, the compounds of the present invention have shown less cardiac effects than known potassium channel activators. Also disclosed is a process for preparing these and other compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.