1.4-dihydro pyridines

US5011848A · kind A · utility

Assignee

• Glaxo SpA · IT

Inventors

• Claudio Semeraro · Bresso, IT
• Dino Micheli · Carpi, IT
• Daniele Pieraccioli · Verona, IT
• Giovanni Gaviraghi · Verona, IT
• Allan D. Borthwick · London, GB

Key dates

• Filing date: Jan 23, 1989
• Grant date: Apr 30, 1991
• Expiry date: Jan 23, 2009

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C03B2205/44
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds are described of the formula ##STR1## wherein R.sub.1 and R.sub.4 independently represent a C.sub.1-4 alkyl group; PA0 R.sub.2 and R.sub.3 independently represent a C.sub.1-6 straight or branched alkyl chain which may be interrupted by an oxygen atom; PA0 R.sub.5 represents a straight or branched chain C.sub.1-13 alkyl group or a C.sub.5-8 cycloalkyl group which may be substituted by a C.sub.1-3 alkyl substitutent; The compounds represented by formula (I) reduce intracellular calcium ion concentration by limiting transmembranal calcium ion influx and thus may be useful for the treatment of cardiovascular disorders such as hypertension.