Diphosphonate-derivatized macromolecules
US5011913A · kind A · utility
43Cited by
6References
6Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 11, 1989 |
| Grant date | Apr 30, 1991 |
| Priority date | — |
| Expiry date | May 11, 2009 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2123/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Diphosphonate-derivatized macromolecules, such as proteins, suitable for use as technetium-99m-based scanning agents and as anticalcification agents are disclosed. The scanning agents are prepared by combining Tc-99m in a +3, +4 and/or +5 oxidation state with the diphosphonate-derivatized macromoleules. Also disclosed are pharmaceutical compositions containing these diphosphonate-derivatized macromolecules and methods for scintigraphic imaging using these diphosphonate-derivatized macromolecules labeled with Tc-99m.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.