Chromogenic cryptahemispherands and their preparation

US5011924A · kind A · utility

Assignees

• Technicon Instruments Corp. · US
• The Regents of the University of California · US

Inventors

• Donald J. Cram · Los Angeles, US
• Eddy Chapoteau · Brooklyn, US
• Bronislaw P. Czech · Peekskill, US
• Carl R. Gebauer · Granite Springs, US
• Roger C. Helgeson · Joshua Tree, US
• Anand Kumar · Southfields, US
• Koon-wah Leong · Ossining, US

Key dates

• Filing date: May 9, 1989
• Grant date: Apr 30, 1991
• Expiry date: May 9, 2009

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N33/84
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The present invention resides in the discovery of a new class of compounds defined herein as "chromogenic cryptahemispherands" useful for the measurement of ions, in particular, ions in aqueous solution, which have the structure ##STR1## wherein: R, same or different, is hydrogen, lower alkyl, lower alkylidene, lower alkenyl, allyl or aryl; PA1 R', same or different, is lower alkyl, lower alkylidene, lower alkenyl, allyl or aryl; PA1 R", same or different, is hydrogen, lower alkyl, lower alkylidene, lower alkenyl, allyl or aryl; PA1 Q is a chromogenic moiety capable of providing the appearance of or change in color, or which is otherwise capable of providing a detectable response in the presence of a particular cation; PA1 a, b, m and n, same or different, are 1 to about 3; and x, y, same or different, are 1 to about 4. PA1 A test device utilizing one or more of the compounds for performing such measurements is also disclosed.