Antihypercholesterolemic alkylene compounds
US5011947A · kind A · utility
10Cited by
0References
14Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 12, 1990 |
| Grant date | Apr 30, 1991 |
| Priority date | — |
| Expiry date | Jun 12, 2010 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/4015
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Compounds of the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 each are independently hydrogen, halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy or trifluoromethyl; PA1 R is C.sub.1-7 alkyl, C.sub.3-6 cycloalkyl, fluoromethyl, difluoromethyl, trifluoromethyl; PA1 A is ##STR2## R.sup.5 is hydrogen, a hydrolyzable ester group or a cation to form a non-toxic pharmaceutically acceptable salt, are novel antihypercholesterolemic agents which inhibit cholesterol biosynthesis. Intermediates and processes for their preparation are disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.