Method for the preparation of .alpha..sup.1 [[(1,1-dimethylethyl)amino]methyl]-4-hydroxy-1,3-benzenedimethanol
US5011993A · kind A · utility
1Cited by
4References
6Claims
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Key dates
| Filing date | Apr 20, 1990 |
| Grant date | Apr 30, 1991 |
| Priority date | — |
| Expiry date | Apr 20, 2010 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C45/46
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
There is disclosed an improved process for preparing albuterol which comprises reacting a 5-(haloacetyl)-2-hydroxybenzaldehyde with 1,1-dimethylethanamine in an organic solvent and in an inert atmosphere to form 5-[[(1,1-dimethylethyl)amino]acetyl]- 2-hydroxybenzaldehyde and reducing the carbonyl functions to the corresponding hydroxy groups to form albuterol.
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