Process for the preparation of optically active secondary amines
US5011995A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jul 19, 1988 |
| Grant date | Apr 30, 1991 |
| Priority date | — |
| Expiry date | Jul 19, 2008 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D217/02
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Asymmetric hydrogenation of prochiral N-aliphatic ketimines to give optically active secondary amines at a temperature from -20.degree. to 80.degree. C., a hydrogen pressure of 10.sup.5 to 10.sup.7 Pa, with the addition of catalytic amounts of an iridium compound of the formula III or IIIa EQU [XIrYZ] (III) EQU or EQU [XIrY].sup..sym. A.sup..crclbar. (IIIa) in which X is two olefin ligands or a diene ligand, Y is a chiral diphosphine the secondary phosphine group of which are attached through 2-4 C atoms and which, together with the Ir atom, forms a 5-membered, 6-membered or 7-membered ring, or Y is a chiral diphosphinite the phosphinite groups of which are attached via 2 C atoms and which, together with the Ir atom, forms a 7-membered ring, Z is Cl, Br or I and A.sup.- is the anion of an oxygen acid or complex acid, and, if appropriate, with the addition of an ammonium chloride, bromide or iodide or an alkali metal chloride, bromide or iodide.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.