L-glutamic acid derivatives

US5013738A · kind A · utility

Assignee

• THE TRUSTEES OF PRINCETON UNIVERSITY · US

Inventors

• Edward C. Taylor · Princeton, US
• Thomas Schräder · Uetersen, DE
• Loren D. Walensky · Newton, US

Key dates

• Filing date: Apr 18, 1990
• Grant date: May 7, 1991
• Expiry date: Apr 18, 2010

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Substituted pyrimidin-5-yl derivatives of L-glutamic acid are anti-neoplastic agents. A typical embodiment is N-{4-[6-(2,6-diamino-4-hydroxypyrimidin-5-yl)hex-1-en-3-yl]benzoyl}-L-glut amic acid.