5-oxime avermectin derivatives
US5015630A · kind A · utility
12Cited by
9References
13Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 19, 1989 |
| Grant date | May 14, 1991 |
| Priority date | — |
| Expiry date | Jan 19, 2009 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H17/08
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Novel avermectin derivatives are disclosed, wherein the 5-hydroxy group is replaced by an oxime group. The avermectin-5-oximes can further be derivatized at the 4"- or 4'-positions as amino, substituted amino, acylhydrazone, semicarbazone, or substituted semicarbazone analogues. The avermectin-5-oximes are prepared by the oxidation of the 5-hydroxy compounds with manganese dioxide or with pyridinium dichromate to the known 5-oxo analogues, and these are then reacted with a hydroxylamine salt. The new compounds are potent anti-parasitic agents, in particular, the compounds are anthelmintic, insecticidal and acaricidal agents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.