Site specific alkylating agents
US5017599A · kind A · utility
11Cited by
5References
5Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 21, 1990 |
| Grant date | May 21, 1991 |
| Priority date | — |
| Expiry date | Feb 21, 2010 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D207/34
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention relates to distamycin A analogs of the following formula ##STR1## wherein n is 2, 3 or 4; A is an optionally substituted divalent radical chosen from ##STR2## and -Het- wherein Het is a pentatomic or hexatomic heteromonocyclic ring, except pyrrole; and wherein either one of R.sub.1 and R.sub.2 is hydrogen and the other is an acylating moiety or R.sub.1 and R.sub.2 are both hydrogen or both alkyl groups optionally substituted, including the pharmaceutically acceptable salts of the said compounds. The compounds of the invention can be useful antitumor and antiviral agents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.