Phosphorous-containing HMG-CoA reductase inhibitors, new intermediates and method
US5017716A · kind A · utility
15Cited by
4References
6Claims
0Family size
Assignee
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Key dates
| Filing date | Dec 1, 1989 |
| Grant date | May 21, 1991 |
| Priority date | — |
| Expiry date | Dec 1, 2009 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/4407
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Compounds which are useful as inhibitors of cholesterol biosynthesis and thus as hypocholesterolemic agents are provided which have the structure ##STR1## including salts thereof, wherein R is OH, lower alkoxy or lower alkyl; R.sup.x is H or alkyl; PA0 X is --O-- or --NH--; PA0 n is 1 or 2 PA0 Z is a hydrophobic anchor, such as ##STR2## wherein the dotted lines represent optional double bonds. New intermediates used in preparing the above compounds, pharmaceutical compositions containing such compounds and a method for using such compounds to inhibit cholesterol biosynthesis are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.