Patent · US Expired

Biocompatible substance with thromboresistance

US5019393A · kind A · utility

89Cited by
11References
37Claims
0Family size

Assignee

Inventors

Key dates

Filing dateAug 3, 1988
Grant dateMay 28, 1991
Priority date—
Expiry dateAug 3, 2008

Classification

  • Technology area (CPC A)Human Necessities
  • CPC primaryA61L33/0029
  • WIPO fieldMedical technology
  • WIPO sectorInstruments

Abstract

Disclosed is a biocompatible, thromboresistant substance useful for implantable and extracorporeal devices in contact with the vascular system, and methods for producing the same. The biocompatible, thromboresistant substance comprises a synthetic, biocompatible material, at least one biocompatible base coat layer adhered to at least one surface of the material, and a thrombogenesis inhibitor immobilized on the base coat layer via a component capable of binding the inhibitor. The thrombogenesis inhibitor is streptokinase, urokinase, tissue plasminogen activator, ATPase, 5'-nucleotidase, and active fragments and active analogs thereof.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.