Benzoyl peroxide--quaternary ammonium lipophilic salicylate based pharmaceutical and cosmetic compositions and their use especially in treatment of acne
US5019567A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Nov 23, 1988 |
| Grant date | May 28, 1991 |
| Priority date | — |
| Expiry date | Nov 23, 2008 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61Q19/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A pharmaceutical or cosmetic composition for topical application comprises, in a physiologically acceptable support, the combination of benzoyl peroxide and at least one quaternary ammonium lipophilic salicylate having general formula (I): ##STR1## where: (i) R.sub.1, R.sub.2, R.sub.3 and R.sub.4 may be identical or different, representing a substituted or interrupted alkyl or cycloalkyl radical; PA0 (ii) R.sub.3 and/or R.sub.4 represent(s) the group: EQU R.sub.8 --OC.sub.2 H.sub.3 R.sub.7 ].sub.n [OCH.sub.2 CHOH--CH.sub.2 ].sub.p PA0 where O.ltoreq.n.ltoreq.4 and p is 0 or 1; R.sub.8 represents H or an alkyl, alkenyl, alkylcycloalkyl or alkylanyl radical; PA0 (iii) R.sub.4 represents an alkylenephenyl radical; PA0 (iv), (v): R.sub.1 and R.sub.2 may form an aromatic or nonaromatic saturated or unsaturated heterocycle; PA0 (vi) R.sub.1, R.sub.2 and R.sub.3 together with nitrogen, may form polycyclic derivatives; and R.sub.5 represents a group having the formula: ##STR2## where n may vary from 0 to 10.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.