N-phenyl-N-(4-piperidinyl)amides useful as analgesics
US5019583A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 11, 1989 |
| Grant date | May 28, 1991 |
| Priority date | — |
| Expiry date | Dec 11, 2009 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P25/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
N-Phenyl-N-(4-piperdinyl)amide derivatives are disclosed having the general formula (I): ##STR1## wherein X is a member selected from the group consisting of alkoxy-carbonyl-lower alkyl, lower alkyl-carbonyloxy-lower alkyl, alkenyloxy-carbonyl-lower alkyl, and (C.sub.1-2)alkoxy-(C.sub.1-2)-alkoxy-carbonyl-lower alkyl, and Ar, R, R.sup.1 and R.sup.2 are defined hereinafter, including isomeric forms thereof and acid addition salts thereof. The compounds exhibit analgesic activity having relatively short durations of analgesic action. The invention embraces the compounds (I), pharmaceutical compositions of (I) and methods of providing analgesia with (I). Also included are certain novel intermediates for making (I).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.