Method of enhancing NMR imaging using chelated paramagnetic ions bound to biomolecules

US5021236A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Heinz Gries · Berlin, DE
• Douwe Rosenberg · Berlin, DE
• Hanns-Joachim Weinmann · Berlin, DE
• Ulrich Speck · Berlin, DE
• Wolfgang Mutzel · Berlin, DE
• Georg-Alexander Hoyer · Berlin, DE
• Heinrich Pfeiffer · Eppingen, DE

Key dates

• Filing date: Mar 2, 1987
• Grant date: Jun 4, 1991
• Expiry date: Mar 2, 2007

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T436/24
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Agents useful for influencing the relaxation times in NMR diagnostics, contain at least one paramagnetic, physiologically compatible complex salt comprising a chelate from an open-chain or cyclic complex-forming compound containing organic nitrogen, phosphorus, oxygen and/or sulfur, and a complexed ion of the lanthanide elements of atomic number 57-70 or of the transition metals of atomic numbers 21-29, 42 and 44, and, optionally, an inorganic or organic base or acid, wherein said chelate complex is bound to a biomolecule.