Imidazolyl alkyl guanidine derivatives, processes for their preparation and pharmaceutical preparations containing these compounds

US5021431A · kind A · utility

Assignee

• Heumann Pharma GmbH · DE

Inventors

• Armin Buschauer · Berlin, DE
• Helmut Schickaneder · Eckental, DE
• Walter Schunack · Berlin, DE
• Sigurd Elz · Berlin, DE
• Istvan Szelenyi · Arnstorf, DE
• Gert Baumann · Pittsburgh, US
• Kurt H. Ahrens · Nürnberg, DE

Key dates

• Filing date: Feb 28, 1989
• Grant date: Jun 4, 1991
• Expiry date: Feb 28, 2009

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

New imidazolylalkyl-guanidine derivatives are described, which by virtue of their agonistic action on histamine-H.sub.2 receptors and in part also due to their additional H.sub.1 -antagonistic receptor activity can be used in the treatment of cardiac diseases, certain forms of hypertension and diseases of arterial occlusion. These imidazolylalkyl-guanidine derivatives correspond to the general formula I: ##STR1##