Antibiotics from myxococcus

US5023184A · kind A · utility

Assignees

• Ciba-Geigy · US
• Gesellschaft fur Biotechnologische Forschung mbH (GBF) · DE

Inventors

• Hans Reichenbach · Braunschweig, DE
• Klaus Gerth · Braunschweig, DE
• Herbert Irschik · Wittmund, DE
• Brigitte Kunze · Braunschweig, DE
• Gerhard Hofle · Braunschweig, DE
• Hermann Augustiniak · Wolfenbüttel, DE
• Norbert Bedorf · Königslutter am Elm, DE
• Rolf Jansen · Braunschweig, DE
• Wolfram Trowitzsch-Kienast · Braunschweig, DE
• Heinrich Steinmetz · Wennigsen (Deister), DE

Key dates

• Filing date: Aug 13, 1987
• Grant date: Jun 11, 1991
• Expiry date: Aug 13, 2007

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12R2001/01
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The invention relates to novel polycyclic alkaloids of formula ##STR1## in which R.sup.1 represents hydrogen or hydroxy, R.sup.2 represents hydrogen or acyl and A and B, independently of one another, each represents C.dbd.O or C--OH, and wherein the dashed line represents a C.dbd.C double bond at the position of the middle bond when A or B represents C.dbd.O, or at the position of the two outer bonds when A or B represents C--OH, a process for the manufacture of these compounds by fermentation of a novel microorganism of the species Myxococcus xanthus, the novel microorganism itself, pharmacetical preparations that contain the novel compounds, and the use of the novel compounds as antibiotics and as tumour-inhibiting agents and for the manufacture of pharmaceutical preparations.