Factor VII/VIIA active site inhibitors
US5023236A · kind A · utility
37Cited by
5References
58Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 13, 1989 |
| Grant date | Jun 11, 1991 |
| Priority date | — |
| Expiry date | Mar 13, 2009 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K5/0827
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention includes a class of compounds that inhibit the specific proteolytic activity of the bimolecular complex 1[TF:VII/VIIa] that initiates the blood coagulation systems. Both reversible and irreversible inhibitors are disclosed. The invention encompasses the use of inhibitors of the active site of the factor VII and VIIa component of [TF:VII/VIIa] as diagnostic reagents, as analytical reagents, and as therapeutic drugs. The invention includes the compounds based on the following general formula for both reversible and irreversible selective inhibition of [TF:VII/VIIa]. ##STR1##
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.