Amine derivatives
US5023378A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 6, 1989 |
| Grant date | Jun 11, 1991 |
| Priority date | — |
| Expiry date | Oct 6, 2009 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C323/25
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention provides compounds of the general formula (I) ##STR1## and physiologically acceptable acid addition salts, metabolically labile esters and solvates thereof in which PA0 R.sup.1 represents a halogen atom or a methyl, ethyl, n-propyl or n-butyl group; PA0 R.sup.2, R.sup.3, R.sup.4 and R.sup.5 each represent hydrogen atoms or one or two of R.sup.2, R.sup.3, R.sup.4 and R.sup.5 represent a methy or ethyl group; PA0 X represents a C.sub.4-7 alkylene chain optionally substituted by one or more C.sub.1-4 alkyl or hydroxyl groups; or optionally containing one or two double or triple bonds; or optionally interrupted by an oxygen or sulphur atom, or by a sulphone (--SO.sub.2 --) or urea (--NHCONH--) group; and PA0 Y represents a phenyl ring optionally carrying one to three substituents selected from hydroxyl, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, amino, carboxamido, C.sub.1-4 alkylsulphonylamino and nitro groups and halogen atoms with the proviso that when X is a C.sub.4-7 alkylene chain optionally containing one double bond then Y cannot represent phenyl or phenyl carrying one substituent which is halogen. The compounds according to the invention decrease total peripheral vascula…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.