Thioether linked immunotoxin conjugates
US5024834A · kind A · utility
39Cited by
3References
5Claims
0Family size
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Key dates
| Filing date | Oct 15, 1990 |
| Grant date | Jun 18, 1991 |
| Priority date | — |
| Expiry date | Oct 15, 2010 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K47/6889
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Heterobifunctional crosslinkers up to about 34 .ANG. in length consisting of a sulfhydryl reactive group linked to a spacer group, which in turn is linked to an activated carboxylate group, that are useful for making efficacious anticancer immunotoxin conjugates as shown preferably by reacting an antibody associated amino group with the activated carboxylate group to form an antibody crosslinker complex and reacting the antibody crosslinker complex with a cytotoxin having a reactive sulfhydryl group with the sulfhydryl reactive group of the crosslinker, and using the conjugates so produced to treat cancer patients.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.