Benzothiazinone derivatives, and pharmaceuticals containing them

US5025010A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Raymond Oekonomopulos · Wiesbaden, DE
• Rainer Henning · Tokyo, JP
• Ulrich Lerch
• Bernward Scholkens · Kelkheim, DE
• Wolfgang Linz · Mainz, DE

Key dates

• Filing date: Oct 17, 1989
• Grant date: Jun 18, 1991
• Expiry date: Oct 17, 2009

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P9/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A description is given of compounds I ##STR1## with R(1) equal to H, alkyl, alkoxy, Hal, NO.sub.2, OH, acetamido or amino; R(2) equal to H, alk(en)yl or phenylalkyl; R(3) equal to H, (cyclo)alk(en)yl(alkyl), phenyl or phenylalkyl; R(4) equal to H, alkyl, alkoxy, Hal CF.sub.3, NO.sub.2, OH, acetamido or amino; A equal to --C.tbd.C-- or --CH.dbd.CH--; R(5) equal to various amines; m and n equal to 1-3; and their salts. Preparation processes are also described. Compounds I are excellent calcium agonists or calcium antagonists. They also act to regulate the blood glucose.