Benzopyran derivatives, their preparation and pharmaceutical compositions containing them
US5025013A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 16, 1990 |
| Grant date | Jun 18, 1991 |
| Priority date | — |
| Expiry date | Jan 16, 2010 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D405/14
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
New benzopyran derivatives of general formula (I) in which: PA1 R.sub.1 represents a hydrogen or halogen atom or a hydroxy, alkyloxy, nitro, amino, alkylsulphonamido or acylamino radical, PA1 R represents PA2 (1) radical ##STR1## R.sub.2 and R.sub.3, which may be identical or different, being H, halogen, OH, alkyl, alkyloxy, NH.sub.2, alkylsulphonamido or NO.sub.2, or PA2 (2) a radical ##STR2## n being 0 or 1, R.sub.4 being H, alkyl or optionally substituted phenyl and Q is acyl, alkylsulphonyl or ##STR3## Y being --CO-- or --SO.sub.2 -- and Z being a single bond, --CH.sub.2 -- or --NH--, or PA2 (3) a radical ##STR4## n being 0 or 1, m being 0 or 2, X being C or N (if n=0), W being a bond or --NH-- and AR being pyridyl, indolyl, quinolyl, 2-alkylquinolyl or phenyl optionally substituted with R.sub.2 and R.sub.3, provided that n=0 when X equals N, or PA2 (4) a radical of general formula: ##STR5## R.sub.7 being H or alkyl, or alternatively (5) a radical ##STR6## R' and R" are identical and represent hydrogen atoms or alkyl radicals, their isomeric forms and the mixtures thereof, and their addition salts with acids. These new products are useful as anti-arrhythmic and antifibrillating…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.