Platinum complexes with one radiosensitizing ligand
US5026694A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 30, 1989 |
| Grant date | Jun 25, 1991 |
| Priority date | — |
| Expiry date | Jun 30, 2009 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F15/0093
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Methods to inhibit tumor growth and to radiosensitize hypoxic cells and pharmaceutical compositions therefor are disclosed. These methods and compositions use compounds of the formula EQU PtX.sub.n (NR.sub.2 H) (L) (1) PA0 wherein n is 1 or 2, and PA0 wherein when n is 2, X is a monovalent biologically acceptable anion, and when n is 1, X is a divalent biologically acceptable anion; PA0 each R is independently H or alkyl, or both Rs together are a piperidino or morpholino residue; and PA0 L is a radiosensitizing ligand selected from a mononitro-substituted imidazole, a mononitro-substituted pyrazole, a mononitro-substituted thiazole and a mononitro-substituted isothiazole.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.