Use of 5,11-dihydro-6H-pyrido[2,3-b][1,4]-benzodiazepin-6-ones substituted in the 11-position for treating bradycardia and bradyarrhythmia in human and veterinary medicine

US5026699A · kind A · utility

Assignee

• Dr. Karl Thomae GmbH · DE

Inventors

• Gerhard Mihm · Biberach, DE
• Wolfgang Eberlein · Biberach, DE
• Welfhard Engel · Biberach, DE
• Gunter Trummlitz · Warthausen, DE
• Norbert Mayer · Gersthofen, DE
• Henri Doods · Warthausen, DE
• Rudolf Hammer · Ingelheim am Rhein, DE

Key dates

• Filing date: Jun 15, 1989
• Grant date: Jun 25, 1991
• Expiry date: Jun 15, 2009

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P15/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

5,11-Dihydro-6H-pyrido[2,3-b][1,4]-benzo-diazepinones substituted in the 11-position corresponding to general formula I ##STR1## wherein R.sup.1 and R.sup.2 represent hydrogen atoms or alkyl groups having 1 to 3 carbon atoms, A.sup.1 is a straight-chained or branched alkylene group with 1 to 5 carbon atoms, A.sup.2 is a methylene group or, if R.sup.1 is hydrogen and R.sup.2 is methyl, A.sup.2 may also be an ethylene group, and the physiologically acceptable acid addition salts thereof are suitable for treating bradycardia and bradyarrhythmia and spasm in the colon, bladder and bronchi.