Benzimidazolylpyridazinones

US5026705A · kind A · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Helmut Prucher · Heppenheim, DE
• Rochus Jonas · Darmstadt, DE
• Jaime Piulats · Barcelona, ES
• Michael Klockow · Lutherstadt Eisleben, DE

Key dates

• Filing date: May 30, 1990
• Grant date: Jun 25, 1991
• Expiry date: May 30, 2010

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

New benzimidazolylpyridazinones of the formula I ##STR1## in which R.sup.1 is a styryl or mononculear of binuclear heteroaryl radical which contains 1-4 heteroatoms, each of which is unsubstituted or singly or multiply substituted by alkyl, alkoxy, alkylthio, halogen, OH, SH, amino, alkylamino, dialkylamino, acylamino having 1-8 C atoms, nitro, COOH, COOalkyl and/or CN, PA0 R.sup.2 R.sup.3, R.sup.4 and R.sup.5 are each H or alkyl and PA0 R.sup.6 and R.sup.7 are each H, or together are a C--C bond, and in which the alkyl and alkoxy groups each contain 1-4 C atoms, and their salts, show positive inotropic, vasodilating and antithrombotic actions.