2-guanidino-4-arylthiazoles for treatment of peptic ulcers
US5026715A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 20, 1989 |
| Grant date | Jun 25, 1991 |
| Priority date | — |
| Expiry date | Oct 20, 2009 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
2-Guanidino-4-arylthiazole compounds of the formula ##STR1## a pharmaceutically acceptable cationic or acid addition salt thereof wherein PA0 R.sup.1 is hydrogen, (C.sub.1 -C.sub.10)alkyl, optionally substituted phenyl or certain optionally substituted aralkyl groups; PA0 R.sup.2 is hydrogen or (C.sub.1 -C.sub.4)alkyl, and PA0 Ar is certain optionally substituted pyrrolyl or indolyl groups; method for their use in treatment of gastric ulcers, by inhibition of parietal cell H.sup.+ /K.sup.+ ATPase, and antiinflammatory conditions in combination with piroxicam, for use in mammals, and pharmaceutical compositions containing said compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.