Solventless process for preparing a tri-substituted triazine
US5026849A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 9, 1989 |
| Grant date | Jun 25, 1991 |
| Priority date | — |
| Expiry date | Jun 9, 2009 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/582
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process is taught for recovering a white reaction product of a cyanuric halide with an amine reactant (white being indicative of the product's high purity), in high yield. In the absence of a solvent for either reactant, the first step comprises reacting the cyanuric halide, as a finely divided solid, with a liquid amine which is to provide a saturated heterocyclic amine group, such as a polysubstituted piperazinone, piperazine, or piperidine as the substituent for each of the three halogen atoms of the cyanuric halide used. This solventless process carried out under essentially anhydrous conditions, with a large molar excess of the amine reactant chosen, not only shortens the long time required to make the desired tri-substitution in a conventional solvent process, but also obviates using a pressurized reactor. Since (i) the reaction temperature is relatively low, (ii) there is no solvent, and (iii) the amine reactants are relatively high-boiling, and the reaction occurs in the liquid phase, there is no build-up of pressure. Fortuitously, the appropriate amount of alkanol and concentrated aqueous alkali provides a partition coefficient such that salt formed by neutralization of …
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