Method for the production of 2-bromo-5,6,7,8-tetrahydroquinoline and the analogous 2-bromo-trimethylene and pentamethylene pyridines
US5026854A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Aug 8, 1990 |
| Grant date | Jun 25, 1991 |
| Priority date | — |
| Expiry date | Aug 8, 2010 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D215/14
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention concerns compounds of formula I ##STR1## or a salt thereof, wherein R.sup.1 and R.sup.2 each independently represent hydrogen, lower alkyl, lower alkoxy, carboxyloweralkyl, carboxy, hydroxyloweralkyl, halogen, haloloweralkyl, lower alkoxycarbonyl, optionally substituted aryl or optionally substituted aralkyl, n represents an integer from 3 to 6; R.sup.3 which is optionally present represents single or multiple substitution on one or more of the aliphatic carbons by one or more substituents selected from lower alkyl, optionally substituted aryl and optionally substituted aralkyl; A represents a group of formula (i) or (ii) below: EQU --CR.sup.4 R.sup.5 --(CR.sup.6 R.sup.7).sub.m -- (i) EQU --CX--(CR.sup.6 R.sup.7).sub.m -- (ii) in which R.sup.4, R.sup.6 and R.sup.7 each independently represent hydrogen or lower alkyl (providing that when R.sup.5 is NH.sub.2, R.sup.4 is hydrogen); m is 0 or 1; R.sup.5 represents hydrogen, NH.sub.2, OH or loweralkoxy, and X is .dbd.O, .dbd.NH or .dbd.NOH, the attachment of A to B being from either end, and B represents an optionally substituted aryl or heteroaryl radical which compounds possess anti-inflammatory activity. Also disclosed …
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.