Cytotoxic antibody conjugates of hydrazide derivatized methotrexate analogs via simple organic linkers
US5028697A · kind A · utility
37Cited by
2References
20Claims
0Family size
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Key dates
| Filing date | Aug 8, 1988 |
| Grant date | Jul 2, 1991 |
| Priority date | — |
| Expiry date | Aug 8, 2008 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Conjugates of antibodies and cytotoxic methotrexate drugs make use of linkers between the drug and antibody which are simple organic groups, wherein the link to the antibody is an acyl group and the link to the drug is an alkylidene hydrazide.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.