Anti-fungal homopropargylamine compounds

US5030625A · kind A · utility

Assignee

• Sandoz AG · CH

Inventor

• Anton Stuetz · Mödling, AT

Key dates

• Filing date: Aug 14, 1989
• Grant date: Jul 9, 1991
• Expiry date: Aug 14, 2009

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K31/695
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to novel homopropargylamines of formula I ##STR1## wherein n is 2 or 3, PA1 R.sub.1 is a group of formula IIa, IIb or IIc ##STR2## in which R.sub.6 and R.sub.7 indpendently are H, halogen, CF.sub.3, lower alkyl or lower alkoxy, PA2 s is a number of 3 to 5, PA2 X is O, S, OCH.sub.2, SCH.sub.2 CH.sub.2 or NR.sub.8, and PA2 R.sub.8 is H or lower alkyl, PA1 R.sub.2 is H or lower alkyl, either PA1 R.sub.3 and R.sub.4, independently, are H or lower alkyl, or PA1 R.sub.3 and R.sub.4 together are (CH.sub.2).sub.u, PA1 in which u is a number of 3 to 5, and PA1 R.sub.5 is H, alkenyl or is a group selected from alkyl, trialkylsilyl, dialkylphenylsilyl, phenyl, phenylalkyl and cycloalkyl, in which alkyl, phenyl and cycloalkyl groups or moieties are unsubstituted or substituted by OH, lower alkyl, lower alkoxy, phenyl or halogen, in free base form or acid addition salt form thereof, their preparation, their chemotherapeutical and agricultural use and to compositions comprising such novel compounds and suitable for such use.