N-aryl-azetidinones, their preparation process and their use as elastase inhibitors
US5030628A · kind A · utility
34Cited by
2References
13Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 19, 1989 |
| Grant date | Jul 9, 1991 |
| Priority date | — |
| Expiry date | Dec 19, 2009 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/568
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention relates to N-aryl-azetidinones, their preparation process and their use as active serine elastase inhibitors. The N-aryl-azetidinones are in accordance with formula: ##STR1## in which R.sup.1 and R.sup.2 can be a halogen atom or an organic radical, R.sup.3 represents a halogen atom or another good starting group and R.sup.4 represents H or an organic radical. The compounds with R.sup.3 .dbd.Cl or OSO.sub.2 CH.sub.3, R.sup.4 .dbd.H and R.sup.1 .dbd.R.sup.2 .dbd.F or R.sup.1 .dbd.F and R.sup.2 .dbd.Br are irreversible and selective elastase inhibitors.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.