Glutaramide diuretic agents
US5030654A · kind A · utility
157Cited by
2References
38Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 19, 1989 |
| Grant date | Jul 9, 1991 |
| Priority date | — |
| Expiry date | May 19, 2009 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D333/34
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A series of novel spiro-substituted glutaramide derivatives have been prepared, including the pharmaceutically acceptable salts thereof and bioprecursors therefor, wherein the spiro-substituent completes a 5- or 6-membered carbocycyclic ring and is located at the carbon atom adjacent to the carbamoyl group. These particular compounds are inhibitors of the neutral endopeptidase E.C.3.4.24.11 enzyme and are therefore useful in therapy as diuretic agents for the treatment of hypertension, heart failure, renal insufficiency and other disorders. Methods for preparing these compounds from known starting materials are provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.