Dual-action tablet
US5032406A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 21, 1989 |
| Grant date | Jul 16, 1991 |
| Priority date | — |
| Expiry date | Feb 21, 2009 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P9/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides a dual-action tablet composition comprising: PA0 (a) an outer tablet comprising a first dose of active ingredient dispersed in a pH independent hydrophilic polymer matrix; and PA0 (b) an inner tablet comprising a second dose of active ingredient in a rapidly disintegrating excipient base. This dual-action tablet is especially efficacious for those active ingredients which have half lives of less than two hours and which experience decreased absorption efficiency in the lower gastrointestinal tract. Among the preferred dual-action tablet compositions is one wherein the active ingredient in both the inner and outer tablets is guaifenesin. Upon administration, the outer tablet provides a controlled release of the active ingredient while the inner tablet gives a second dose of active ingredient after the outer tablet has partially dissolved.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.