Process for producing compounds containing a terminal hydroxyl or epoxy group and microorganisms suitable therefor
US5032512A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 14, 1988 |
| Grant date | Jul 16, 1991 |
| Priority date | — |
| Expiry date | Jan 14, 2008 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P17/02
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
This invention relates to a process for the microbiological production of compounds containing a terminal hydroxyl or epoxy group from an aliphatic substrate or a substrate with an aliphatic side chain, using microorganisms genetically engineered so that they have retained their capacity to perform the terminal oxidation of the substrate, but are no longer able to convert the resulting oxidation product further to any significant extent. Preferred substrates are n-alkanes, n-alkenes, and n-alkadienes containing 6-12 carbon atoms. Preferred micro-organisms are genetically engineered Pseudomonas oleovorans and Pseudomonas putida strains lacking an active plasmidic alkanol-dehydrogenase gene. The invention also relates to micro-organisms thus genetically engineered.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.