DNA sequences encoding infectious bronchitis virus spike protein
US5032520A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Nov 4, 1986 |
| Grant date | Jul 16, 1991 |
| Priority date | — |
| Expiry date | Nov 4, 2006 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2770/20022
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The problem of diagnosis and typing of infectious bronchitis virus in poultry has been solved and important progress made towards an IBV vaccine by this invention. DNA complementary to the region of genomic IBV RNA which codes for a spike protein polypeptide comprising the S1 polypeptide (containing antigenic determinants) or the S2 polypeptide (containing means for anchoring the spike protein to the viral membrane) has been made. It can be carried by a cloning vector, incorporated in a host and cloned. It can also be cloned in a poxvirus which is used to transfect mammmalian cells. Such cells express an artificial spike protein polypeptide.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.