Method for treating fungal infections with amphotericin B/cholesterol sulfate composition
US5032582A · kind A · utility
28Cited by
2References
6Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Mar 8, 1989 |
| Grant date | Jul 16, 1991 |
| Priority date | — |
| Expiry date | Mar 8, 2009 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K47/28
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
An amphotericin B composition containing particles of amphotericin B and cholesterol sulfate, in a molar ratio of between about 1:1 to 1:4. The particles, when stored in lyophilized form and reconstituted in an aqueous suspension, have particle sizes predominantly between aobut 100-400 nm. The composition formed at a molar ratio of about 1:1 amphotericin B:cholesterol sulfate has stable particle sizes in an aqueous suspension over a several-day storage period. The composition is significantly less toxic and more effective in treating fungal infections than prior amphotericin B formulations.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.