Vinblastine synthesis
US5034320A · kind A · utility
1Cited by
0References
5Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Mar 31, 1987 |
| Grant date | Jul 23, 1991 |
| Priority date | — |
| Expiry date | Mar 31, 2007 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P17/182
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The reaction of 3',4'-anhydrovinblastine with a Catharanthus roseus-derived protein fraction to form vinblastine is improved by conducting the reaction in the presence of a reducing agent such as the enzyme cofactor NADH. A cationic species such as manganous ion may also be added to the reaction. Vinblastine yields are enhanced.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.