Piperazinylalkyl-3(2H)-pyridazinones and the use thereof as agents lowering blood pressure

US5034391A · kind A · utility

Assignee

• CL Pharma Aktiengesellschaft · AT

Inventors

• Heinz Blaschke · Linz, AT
• Heimo Stroissnig · Wien, AT
• Harald Fellier · Puchenau, AT
• Rita Enzenhofer · Leonding, AT

Key dates

• Filing date: Nov 30, 1989
• Grant date: Jul 23, 1991
• Expiry date: Nov 30, 2009

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D403/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to new piperazinylalkyl-3(2H)-pyridazinones of the formula ##STR1## in which the radicals R.sub.1 represents hydrogen, phenyl, benzyl, or (C.sub.1 -C.sub.6)-alkyl which is unsubstituted or substituted one or more times by hydroxyl, piperidine, morpholine or by a group NR.sub.4 R.sub.5 in which R.sub.4 and R.sub.5 can be identical or different and which represent hydrogen, methyl or ethyl, PA0 R.sub.2 and R.sub.3 represent hydrogen, halogen, (C.sub.1 -C.sub.6)-alkoxy or (C.sub.1 -C.sub.6)-alkyl, where at least one of the radicals R.sub.2 or R.sub.3 denotes hydrogen, PA0 R.sub.6 represents hydrogen, (C.sub.1 -C.sub.4)-alkyl, phenyl, benzyl or phenylethyl, PA0 B represents (C.sub.1 -C.sub.7)-alkylene which is unsubstituted or substituted one or more times by hydroxyl, (C.sub.1 -C.sub.4)-alkyl or by the group NR.sub.4 R.sub.5 and which can optionally be closed to form an alicyclic 4- to 7-membered ring, PA0 R.sub.8 and R.sub.9, which can be identical or different, represent hydrogen or (C.sub.1 -C.sub.6)-alkyl and PA0 Z represents phenyl, naphthyl, pyridyl or thiazolyl, each of which can be unsubstituted or substituted one or more times by (C.sub.1 -C.sub.6)-alkyl…