Uncharged morpholino-based polymers having achiral intersubunit linkages
US5034506A · kind A · utility
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Key dates
| Filing date | Dec 20, 1989 |
| Grant date | Jul 23, 1991 |
| Priority date | — |
| Expiry date | Dec 20, 2009 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01J2219/0072
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A polymer composition is disclosed composed of morpholino subunit structures which are linked together by uncharged, achiral linkages. These linkages are one to three atoms in length, joining the morpholino nitrogen of one subunit to the 5' exocyclic carbon of an adjacent subunit. Each subunit contains a purine or pyrimidine base-pairing moiety effective to bind by hydrogen bonding to a specific base or base-pair in a target polynucleotide.
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