Method for the production of 3-methyl cephem derivatives
US5034522A · kind A · utility
2Cited by
1References
16Claims
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Assignee
Inventor
Key dates
| Filing date | Aug 27, 1990 |
| Grant date | Jul 23, 1991 |
| Priority date | — |
| Expiry date | Aug 27, 2010 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D501/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A method for obtaining improved cophalexin monohydrate or cephradine monohydrate yields and purities in the syntheses of such materials by the acylation of silyl esters of 7-ADCA, which involves admixing a cephalexin or cephradine-containing system with base to separate the acid acceptor employed during acylation from the product, and thereafter separating the aqueous phase containing the cephalosporin anion from the organin phase containing the acid acceptor, to thereby prevent contamination of the desired product by the acid acceptor.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.