Process for the production of thiophosphoric acid esters of hydroxypyrimidines
US5034529A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Mar 3, 1989 |
| Grant date | Jul 23, 1991 |
| Priority date | — |
| Expiry date | Mar 3, 2009 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/6512
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
In a process for the production of a thiophosphoric acid ester of formula I ##STR1## wherein R.sub.1 is lower alkyl, lower alkenyl, lower alkoxy(lower)alkyl or lower alkylmercapto(lower)alkyl, R.sub.2 is hydrogen, lower alkyl or lower alkenyl and R.sub.3 and R.sub.4 are lower alkyl, which comprises reacting a dialkyl phosphoric acid halide of formula II ##STR2## wherein Hal is chlorine or bromine and R.sub.3 and R.sub.4 are as defined hereinabove, with a hydroxypyrimidine of formula III ##STR3## wherein R.sub.1 and R.sub.2 have the significance given to them above, at elevated temperatures and in the presence of an organic solvent and an acid-binding agent, the improvement which comprises adding the reactant of formula II to an essentially dry mixture of the hydroxypyrimidine of formula III and the acid-binding agent in the presence of a low molecular weight water-insoluble aliphatic or cycloaliphatic ketone as organic solvent after removing the water of reaction from said mixture.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.