Phenylbutyl nitrone compositions and methods for prevention of gastric ulceration
US5036097A · kind A · utility
Assignees
Inventors
Key dates
| Filing date | Mar 9, 1990 |
| Grant date | Jul 30, 1991 |
| Priority date | — |
| Expiry date | Mar 9, 2010 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compositions containing PBN, or active derivatives thereof, in a suitable pharmaceutical carrier for administration to a patient, are disclosed for treating or preventing gastric ulceration caused by ingestion of non-steroidal anti-inflammatories. Based on animal studies, the dosage is in the range of 3 to 300 mg/kg and is administered prior to, simultaneously, or shortly after ingestion of the NSAID compound(s). In the preferred embodiment, the range is between 10 and 30 mg/kg, depending on the dosage unit required to protect the mucosa. The preferred method of administration is orally, alone or in combination with the non-steroidal anti-inflammatory. It The United States Government has certain rights in this invention by virtue of grants from the National Institutes of Health.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.