Piperazine derivatives, uses thereof and pharmaceutical compositions containing them

US5037828A · kind A · utility

Assignee

• Boehringer Mannheim GmbH · DE

Inventors

• Gisbert Sponer · Hemsbach, DE
• Harald D. Borbe-Volmer · Mainz, DE
• Jurgen Engel · Alzenau, DE
• Bernhard Kutscher · Maintal, DE
• Georg Niebch · Rodenbach, DE
• Marianne Siebert-Weigel · Frankfurt, DE

Key dates

• Filing date: Jun 6, 1990
• Grant date: Aug 6, 1991
• Expiry date: Jun 6, 2010

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P15/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides compounds of the general formula: ##STR1## wherein R.sub.1 is a hydroxyl group or a methoxy radical, R.sub.2 is a hydrogen atom or a hyroxyl group and R.sub.3 is a hydrogen atom or a hydroxyl group, with the proviso that R.sub.2 and R.sub.3 are not simultaneously hydrogen atoms when R.sub.1 is a methoxy radical; and the pharmacologically acceptable salts thereof. The present invention also provides processes for the preparation of these compounds and pharmaceutical compositions containing them.