Novel thiouracyl derivatives, pharmaceutical compositions containing them and process for preparing same
US5037830A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 29, 1990 |
| Grant date | Aug 6, 1991 |
| Priority date | — |
| Expiry date | Mar 29, 2010 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D401/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to novel compounds of the formula (I), ##STR1## wherein R.sub.1 and R.sub.2 stand independently from each other, for hydrogen, C.sub.1-4 alkyl, phenyl, phenyl-C.sub.1-4 alkyl, piridyl or piridyl-C.sub.1-4 alkyl group; PA0 E means a straight or branched, saturated hydrocarbon chain containing 1 to 6 carbon atoms; PA0 R.sub.3 represents: a phenyl group ortho-substituted by a C.sub.2-5 alkanoylamino, N-C.sub.2-5 alkanoyl-N-C.sub.1-4 alkylamino or di(C.sub.1-4 alkyl)amino group and optionally further substituted by halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy or C.sub.2-5 alkanoyloxy group; or a pyridyl group optionally mono- or polysubstituted by halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, C.sub.2-5 alkanoyloxy or phenyl-C.sub.1-4 alkoxy group as well as their acid addition salts and tautomeric forms of these compounds. The compounds according to the invention show gastric acid secretion-inhibiting and cytoprotective effects and are useful for the treatment of ulcers of the gastrointestinal system.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.