Synthetic polymeric drugs
US5037883A · kind A · utility
Assignees
Inventors
Key dates
| Filing date | Nov 17, 1989 |
| Grant date | Aug 6, 1991 |
| Priority date | — |
| Expiry date | Nov 17, 2009 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/816
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A polymeric drug comprising an inert synthetic polymeric carrier combined through aminoacid or peptide spacers with a bioactive molecule, a targeting moiety, and an optional cross-linkage, comprises: PA1 (a) 5.0 to 99.7 mol % of units derived from N-(2-hydroxypropyl)methacrylamide, PA1 (b) 0.2 to 20.0 mol % of units derived from an N-methylacrylcylated peptide, the peptide groups being bound to a bioactive moiety, PA1 (c) 0.1 to 94.8 mol % of units derived from N-methacrylamide, N-methacrylic acid or an N-methacrylolated aminoacid or peptide, to which are bound a determinant capable of interacting with specific receptors on cell surfaces, PA1 (d) optionally, 0 to 5 mol % of units derived from an N-methacryloylated peptide, the peptide groups being bound to a linking group which is similarly to a similar peptide group attached to another polymer chain, and PA1 (e) optionally, as a bioassay label, 0 to 2 mol % units derived from N-methyacryloylated tyrosinamide.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.