NMR imaging with paramagnetic polyvalent metal salts of poly-(acid-alkylene-amino)-alkanes
US5039512A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 15, 1987 |
| Grant date | Aug 13, 1991 |
| Priority date | — |
| Expiry date | Jun 15, 2007 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T436/24
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
In a method of imaging body tissue in a patient, comprising administering to the patient an effective amount of a pharmaceutical agent for effecting the relaxation times of atoms in body tissues undergoing NMR diagnosis, whereby image contrast is enhanced, said agent comprising an amount, effective to effect such relaxation times, of a paramagnetic, physiologically compatible salt of a physiologically compatible chelate complex of an ion of a lanthanide element of atomic numbers 57-70, or of a transition metal of atomic numbers 21-29, 42, or 44; and a pharmaceutically acceptable carrier, and subjecting the patient to NMR tomography, the improvement wherein said salt of said chelate complex is the calcium or magnesium salt. Such salts are new as are some of the complexing chelates.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.