Process for preparing antigen fractions designed for the detection of antibodies indicative of a cardiovascular risk condition and their use in the diagnosis of a cardiovascular risk condition
US5039608A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 18, 1988 |
| Grant date | Aug 13, 1991 |
| Priority date | — |
| Expiry date | Aug 18, 2008 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/827
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The invention relates to a process for preparing antigen fractions designed for the detection of antibodies, the presence of which, in a certain quantity, in the human blood serum correlates with a cardiovascular risk condition. An arterial tissue is ground, freed of lipids and is subjected to the action of at least one agent selected from the group formed by an aqueous solution of an alkali metal salt or of an alkaline-earth metal salt at ambient temperature, of a hot acid of urea, of guanidine and proteolytic enzymes. The invention also relates to antigen fractions thus obtained and their utilization in the diagnosis of a cardio-vascular risk condition by counter-current electrophoresis or by an ELIFA test or an ELISA test.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.