Aminoglycoside composition having substantially reduced nephrotoxicity induced by the aminoglycoside
US5039666A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Oct 30, 1990 |
| Grant date | Aug 13, 1991 |
| Priority date | — |
| Expiry date | Oct 30, 2010 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention relates to an aminoglycoside composition having reduced nephrotoxicity induced by the aminoglycoside which comprises a selected aminoglycoside and a compound present in an effective amount selected from the group consisting of (a) at least one 7-(oxoalkyl)1,3-dialkyl xanthine of the formula ##STR1## in which R.sub.1 and R.sub.2 are the same or different and are independently selected from the group consisting of straight-chain or branched alkyl radicals with 2 to 6 carbon atoms, cyclohexyl, straight-chain or branched chain alkoxyalkyl and hydroxyalkyl radicals; and A is a hydrocarbon radical with up to 4 carbon atoms which can be substituted by a methyl group; (b) a compound of the formula ##STR2## wherein at least one of R.sub.3 and R.sub.4 is a branched hydroxyalkyl group of the formula ##STR3## with a tertiary alcohol function, which R.sub.6 stands for an alkyl group with 1 to 3 carbon atoms and n stands for a whole number from 2 to 5, the other R.sub.3 or R.sub.4 group that may optionally be present stands for a hydrogen atom or an aliphatic hydrocarbon group R.sub.7 with up to 6 carbon atoms, whose carbon chain may be interrupted by up to 2 oxygen atoms or may b…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.