Antithrombotic substituted cycloalkano(B)dihydroindole- and -indole-sulphonamides and use

US5039670A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Horst Boshagen · Haan, DE
• Ulrich Muller · Wuppertal, DE
• Ulrich Rosentreter · Binnen, DE
• Erwin Bischoff · Wuppertal, DE
• Volker-Bernd Fiedler · Leverkusen, DE
• Elisabeth Perzborn · Wuppertal, DE
• Joachim Hutter · Leverkusen, DE
• Peter Norman · Warwick, GB
• Nigel J. Cuthbert · Tiverton, GB
• Hilary P. Francis · Kenilworth, GB
• Marie G. McKenniff · Slough, GB

Key dates

• Filing date: Oct 17, 1990
• Grant date: Aug 13, 1991
• Expiry date: Oct 17, 2010

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P37/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Substituted antithrombotic substituted cycloalkano[b]-dihydroindole- and -indole-sulphonamides for treatment of thromboses, thromboembolisms, ischemias, asthma and allergies, of the formula ##STR1## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are hydrogen or other radicals, PA1 X is aryl, alkyl or CF.sub.3, PA1 m and Z each is 1,2,3 or 4, PA1 n is 0, 1 or 2, PA1 A is a bond or --NH--, and PA1 Y is OH, alkoxy, aryloxy, amino or sulphonylamine, with the proviso that, in all cases, two of the substituents R.sup.1 -R.sup.4 are other than hydrogen in the event that m represents the number 2 and Y represents the hydroxyl group, or a salt thereof.