Tetrazole amide derivatives of heterocyclic alkenyl acid and their use as antiallergic substances

US5039684A · kind A · utility

Assignee

• Valeas S. p. A. · IT

Inventors

• Virgilio Bernareggi · Cologno Monzese, IT
• Fausto Bonifacio · Milano, IT
• Maurizio Fano · Milano, IT
• Luciano Trabella · Valenza, IT
• Giandomenico Battigelli · Bareggio, IT
• Davide Montagna · Milano, IT

Key dates

• Filing date: Feb 23, 1990
• Grant date: Aug 13, 1991
• Expiry date: Feb 23, 2010

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Tetrazole amide derivatives of heterocyclic alkenyl acids, of general formula ##STR1## in which Y=NH, O or S when m=1; PA0 Y=N when m=2; PA0 m=1 or 2; PA0 l=0 or 4; PA0 R=H, C.sub.1-4 alkyl, Cl, Br, CF.sub.3, CH.sub.2 OCOCH.sub.3, or OCH.sub.2 -Ph; PA0 R.sub.1 =H, alkaline metal or alkaline earth metal, the double bond of the alkenyl chain being of trans or cis configuration and the possible benzene ring being unsubstituted or substituted. Such derivatives possess high antiallergic activity.